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However, after 40 to 42 weeks, no significant difference in estimated glomerular filtration rate was observed

That makes prevention just as important as treatment

PubMed, Nakken, B., et al

GLP-1 RA mimic the incretin hormones through induction of GLP-1 receptor activity

In some cases, discontinuation of the GLP-1 receptor agonist may be necessary if fatigue significantly impairs daily functioning and cannot be adequately managed through supportive measures