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It has been shown to exert various beneficial effects on pancreatic -cells, such as the enhancement of glucose-dependent insulin secretion (27), the acceleration of -cell proliferation and the inhibition of -cell apoptosis (28)

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The clinical effects of these medications go beyond glycemic control, and that is what I want to address directly

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M., Du, Y., Lou, J., Gurbuz, S., & Coskun, T

These alternate metabolic routes lead to accumulation of toxic intermediates and advanced glycation end products, promoting inflammation, cellular dysfunction, apoptosis, and fibrosis within kidney tissues [24,25]