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Across agents, the available human pregnancy-exposure data remain sparse, exposure timing is heterogeneous, and existing studies are underpowered for rare outcomes

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[29] See the $50 GLP-1 Bridge section above for what's covered today, and the BALANCE Model note below for the separate, indefinitely-delayed permanent program

A history of active cancer is a major contraindication for these therapies, as growth-stimulating hormones could theoretically influence tumor growth

Zhang et al., 2023) and with a transformation from A2 (neuroprotective) astrocytes to A1 (neurotoxic) astrocytes, resulting in damage to the hippocampus and impaired spatial learning (She et al., 2022)

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