glp-1 exhaustion Feeling tired on your GLP-1? 😴 Fatigue is often your body adapting How Long Does GLP-1 Fatigue

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PMID: 12667669

Additionally, liver volume decreased significantly, and improvements were observed in biomarkers of hepatic injury and inflammation, suggesting potential antifibrotic and anti-inflammatory properties in these models

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Thus, for a number of them, even if they are good substrates in vitro , other clearance pathways may be more important in vivo or, if they are cleaved by DPP-4, removal of the N-terminal dipeptide may have no effect upon their biological activity

doi:10.1186/s12937-017-0229-6 19