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The SURMOUNT trials showed continued improvement in depression scores through week 72

Folates are sensitive to heat, atmospheric oxygen, UV radiation (e.g., present in sunlight), electron-beam radiation, and reducing sugars (such as fructose) 66,79,86,90,106,123,292,295,306,318,335,336,337,338,339,340,341,342,343,344,345,346,347,348,349,350,351,352,353,354,355

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So when someone quotes about 1 in 5 people get nausea and someone else says more like half, the difference is dose and indication, not disagreement