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PYC is generally well-tolerated, with a low incidence of adverse effects (1.8%) reported across 70 clinical studies

doi: 10.3390/ijms17050636 277 TollerveyJ

North American Society for Pediatric Gastroenterology, Hepatology and Nutrition suggests amitriptyline as the first-line treatment in children older than 5 years (145, 154)

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Pentelute is a co-founder and involved with several companies focusing on the development of protein and peptide therapeutics