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Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation

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One potential reason leptin has not panned out as a therapy on its own is a phenomenon known as leptin resistance. Thats when the body becomes desensitized to the hormone at higher levels, causing a person to feel hungry and eat more even though they have sufficient body fat

In clinical trials, semaglutide has provided clinically relevant reductions in CV risk factors such as excess body weight [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]