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Ishy PL et al, Acta Psychiatr Scand 2017;136(1):5262)

2026 Apr 1;142(4):635-638

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For instance, post hoc analyses from SURMOUNT-1 through SURMOUNT-4 [73] and from across the SURPASS program [74] showed that weight reduction with tirzepatide was neither solely nor fully associated with reported gastrointestinal adverse events, challenging the traditional assumption that nausea and vomiting are significant mediators of weight reduction

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