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[PMID: 33026101 DOI: 10.1111/eci.13423] [DOI] [PMC free article] [PubMed] [Google Scholar] 2.Gavriatopoulou M, Korompoki E, Fotiou D, Ntanasis-Stathopoulos I, Psaltopoulou T, Kastritis E, Terpos E, Dimopoulos MA

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Clinically, this has been highlighted using pharmaceutical CBD (Epidyolex) in epilepsy, where dose escalation has resulted in a four- to five-fold increase in the active clobazam metabolite N-clobazam, required dose adjustments due to significant adverse effects (Karaniewicz-ada et al., 2021)