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Cortisol Awakening Response (CAR): An add-on test to the ASI that provides a more detailed assessment of HPA axis function

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The high dose was initiated at a dose of 5 mg/160 mg and titrated to the randomized dose after 1 week

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Keep in mind that about 14% of people taking semaglutide may lose less than 5% of their body weight after 68 weeks, so for some, exploring alternatives like tirzepatide designed to target multiple hormone receptors might be necessary