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Under the condition of stress reactions such as fever, infection, or increased metabolic stress, patients with methylmalonic acidemia may manifest symptoms of acute metabolic decompensation such as impaired level of consciousness, hypotonia complicated by hyperammonemic encephalopathy, respiratory distress, acidosis, etc

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Excrecin: se excreta principalmente por heces en un 95-97%, y de sta el 87% es como compuesto intacto