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45 An excessive influx of positive ions can trigger immunoexcitotoxicity and neuronal cell death

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Biomarkers will also be important to provide evidence that a drug affects the underlying pathophysiology of the disease, which, together with a beneficial effect on the clinical course, will be essential for labeling the drug as having a disease-modifying effect

Messlinger K

At the lower doses used for diabetes, they have somewhat lower rates of diarrhea (9-12% for Ozempic, 12-21% for Mounjaro) compared to their weight management counterparts

They can lead to disruption of the skin barrier and loss of hydration, worsening the lip condition