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When comparing the GHR/ mouse (lacking GH action) to double- Ghr/IGF-1 mutants (lacking GH and IGF action), the observed growth reduction of the double Ghr/IGF-1 mutants was more severe than that of either single mutant model [31]

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doi: 10.3389/fcvm.2022.900381 28 ZhouXJinMLiuLYuZLuXZhangH