demonstrated that PET NPs (size and dose not reported) can skew the immune balance towards a pro-inflammatory phenotype (shift to Th1/Th17), disrupt immune regulation by decreasing Treg cells and IL-2, and potentially contribute to the development of immune-mediated disorders through increased secretion of pro-inflammatory cytokines and reduced regulatory signalling [87]
5.4.4 PCs and diabetic foot ulcer Diabetic foot ulcers (DFU) are severe and common complications stemming from a multifactorial interplay of sensory, motor, autonomic, and vascular abnormalities, along with altered foot biomechanics (McDermott et al., 2023)
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Cisplatin causes reduction in glomerular filtration and tubular damage, and patients receiving this drug may have an increased loss of carnitine through the kidney [69]
The primary concerns cited included an absence of human exposure data and limited safety characterization.8 That decision significantly narrowed patient access to KPV through licensed compounding channels