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(2015) discovered that exendin-4 treatment in Glp1r+/+ mice elevated cAMP levels in isolated intraepithelial lymphocytes while reducing the transcription of multiple inflammatory mediators, including IL-1, IL-6, IL-22, IL-12, TNF-, CCL2, CXCL1, and CXCL2

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Thereby, patients achieved rapid and robust weight loss efficacy and attained multiple cardiovascular and metabolic benefits, including reduced waist circumstance, blood pressure, blood lipids, transaminase as well as reduced serum uric acid