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Key Takeaway: Feeling cold is often an indirect result of a caloric deficit and the loss of insulating body fat rather than a direct toxic reaction to the medication

General cell culture and imaging The HeLa cell line used in this study was purchased from American Type Culture Collection (ATCC) and grown in DMEM (Gibco, 11965) media supplemented with 10% FBS and 1% 1003 Pen Strep (Gibco)

A growing body of evidence suggests that reactive oxygen species (ROS) are implicated in OA pathogenesis by triggering oxidative stress 2,8,9

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