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Vitamin B12 is needed for conversion of homocysteine and therefore can help prevent conditions or complications like heart attack, stroke or coronary heart disease

In preclinical data, the pair improves adipocyte NAD+ by inhibiting NNMT, resulting in better fat metabolism and reduced obesity.[8][3] For anti-aging, this translates to improved tissue resilience and reduced senescence

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NAD+ itself is the coenzyme that mitochondria burn through to make ATP and that sirtuins and DNA-repair enzymes consume as fuel

Different mechanisms, different side-effect profiles

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