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Bulky side-chain substituents destabilize this arrangement due to steric crowding, so this beta-sheet conformation is usually limited to peptides having a large amount of glycine and alanine

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Vitamin B12 injections are primarily utilized to treat or prevent a deficiency of this vitamin, which is particularly prevalent among older adults due to age-related changes in nutrient absorption

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With the simple composition of GSH, the biosynthesis is simply done by a single bifunctional enzyme, gshF (bifunctional glutathione synthesis enzyme) (Figure 1)

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