Understanding these mechanisms is beneficial for the development of agents in RA
Weight-based dosing provides a more individualized approach than flat-dose recommendations
External and iatrogenic causes: Excessive supplementation: High-dose oral supplements or frequent intramuscular injections (hydroxocobalamin or cyanocobalamin) can elevate serum levels, though this rarely causes problems
A clinical series published in the Journal of Clinical Medicine found that patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) who received intermittent intravenous saline infusions over a 9-week period showed beneficial effects in managing symptoms of dysautonomia and postural orthostatic tachycardia syndrome (POTS)
Each injection should contain at least 5,000 mcg of pharmaceutical-grade methylcobalamin to be effective, and most patients notice improvements in energy, sleep, and mood within weeks of starting proper B12 therapy
this was not included in the tool since the definition of outliers is subjective
