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These first weeks are also when gastrointestinal effects such as bloating, burping, nausea, constipation, and diarrhea often begin

doi:10.1042/bj3100203 65

Wilding, D.M., et al

[10] [11] It's important to understand that GLP-1 medications are initiated at a low dose and gradually increased over several weeks to minimise gastrointestinal side effects such as nausea and vomiting

NICE Technology Appraisal 875 (TA875) recommends semaglutide for weight management within specialist weight management services, typically for people with a BMI 35 kg/m with a weight-related comorbidity, or 30-34.9 kg/m in certain circumstances, alongside dietary modification and increased physical activity