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In interviews, several of them said theyd welcome clinical trials

Higher doses may increase gastrointestinal side effects without improving outcomes

This is the benefit most searchers actually care about, and it's also the one where expectations tend to run ahead of the evidence

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Luciferase activity was significantly reduced in SYNCRIP-deficient cells, indicating that SYNCRIP enhances SIRT1 mRNA stability through interaction with the SIRT1 3' UTR (Figure 5D-G)

Combined senolytic + mitochondrial approaches are an area of active longevity research interest.