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As in the previous recommendations by the ADA and EASD (73, 74), life-style intervention (with patient education and motivation, increase of physical activity, and healthy eating) is still in the beginning and center of therapy, followed by pharmacological therapy with metformin (7074)

[38] Criterion B: There must be evidence that the person has attempted to stop hair-pulling behavior

Figure 5 5.1 Crosstalk among TGF-/Smad-signaling pathway, integrins, and ECM The pleiotropic cytokine TGF- is a multifaceted regulator that affects fundamental biological processes such as cell division, proliferation, apoptosis, and tissue homeostasis

By acting as a long-acting amylin analog, it tackles weight control through a unique mechanism: slowing gastric emptying, boosting satiety, and reducing overall caloric intake

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