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As previously mentioned, examples of longevity resulting from disruption of the GH/IGF-1 and/or insulin signaling pathway are mainly derived from early life manipulations 6,17,18 , whereas brief exposure to GH (and IGF-1) treatment early in development is sufficient to partially abrogate the exceptional longevity of Ames Dwarf mice 20

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Insulin-like growth factor (or IGF-1) is a hormone present in our blood

We identified a lineage of Nestin-Cre ER ::ROSA26-EYFP +/ mice that did not display any leaky YFP expression in the entire femur with vehicle injection ( n =5) (Figure 1B, left panel)

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The neuroprotective mechanisms of GHK-Cu involve sophisticated modulation of neuronal copper metabolism and oxidative stress responses