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Low Neurobiol Dis Sleep Deprivation Reduces Testosterone and Estrogen Sleep deprivation directly reduces both testosterone and estrogen production

Giannopoulos-Dimitriou A, Saiti A, Petrou A, Vizirianakis IS, Fatouros DG

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[1] In a 12 week randomised clinical trial, subjects receiving AOD9604 lost, on average, 1.8 kg more than those receiving placebo

Consistent upregulation of IGFBPs such as IGFBP-2, IGFBP-4, and IGFBP-7 in patient cohorts, together with their strong correlation with hemodynamic severity and survival, highlights their value as both mechanistic drivers and clinically actionable biomarkers