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Efficacy and safety of sildenafil added to pirfenidone in patients with advanced idiopathic pulmonary fibrosis and risk of pulmonary hypertension: a doubleblind, randomised, placebocontrolled, phase 2b trial

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IV drip ensures better absorption and is often used with supportive vitamins such as C and B to enhance results

After 28 days, discard and open a new vial

Chronic conditions and post-surgical recovery extend the protocol to 6 to 12 weeks, with practitioner-guided cases running 16 weeks under close monitoring