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At the level of adipose tissue, GIPR activation promotes fatty acid uptake during energy surplus and fatty acid release during energy deficit, effects that complement the appetite suppression driven by GLP-1R
Many areas offer tier 2 or tier 3 weight management services that integrate behavioural, dietary, and physical activity interventions with pharmacological treatment
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They enhance the results of disciplined habits, rather than replacing them
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Sanjeev Sockalingam echoed the call for clinical assessment, writing that pharmacotherapy "should only be considered after a full clinical assessment by a healthcare professional competent in evidence-based obesity care" [Source: obesitycanada.ca/news/health-canada-generic-semaglutide-approval/]
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