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Referral to gastroenterology should be considered for patients with refractory symptoms despite optimal primary care management, or when the diagnosis is uncertain

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Br Med Bull 115(1):111121 Knoop J, van der Leeden M, van der Esch M, Thorstensson CA, Gerritsen M, Voorneman RE et al (2012) Association of lower muscle strength with self-reported knee instability in osteoarthritis of the knee: results from the Amsterdam Osteoarthritis cohort

Genetic predispositions in GIPR, GLP1R, and FTO variants, when interpreted with a qualified healthcare provider, can support more informed discussions about dosing strategy and formulation choice