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Contrasting with its enhanced effects on blood glucose modulation, exendinphe1 led to a similar degree of appetite suppression as exendin4 and less pica behaviour (a mouse correlate of nausea)

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What persists is the downstream melanogenesis cascade: once MC1R is activated on melanocytes, those cells continue producing eumelanin through enzymatic pathways (tyrosinase, TYRP1, DCT) that don't require continuous peptide presence