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Drug-induced fever is a diagnosis of exclusion and typically presents with specific characteristics, including temporal relationship to drug initiation, resolution upon discontinuation, and recurrence upon rechallenge

Decarboxylation of L-DOPA results in synthesis of the neurotransmitter dopamine .[i] Once converted into dopamine , the enzyme dopamine-beta-hydroxylase converts it into the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline)

Impairment of the MC4R pathway leads to decreased satiety signaling, hyperphagia, and reduced energy expenditure

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