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In preclinical research, blocking NNMT raised NAD+ inside fat cells, increased their metabolic activity, and reduced fat-cell size notably without changes to diet

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In that previous study (which enrolled 377 T2DM and 4741 nondiabetic controls), the prevalence of insomnia in T2DM patients was significantly higher than in nondiabetic controls, in which the prevalence of insomnia was only 12.2% [2]

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