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Behind the scenes, however, a new generation of GLP-1 medications is moving through clinical trials, with oral options, combination therapies and strong early results

First, some relieving news: As of now, there is no sound scientific evidence that suggests GLP-1s directly increase the risk of osteoporosis or osteomalacia, Marci Laudenslager, MD, an obesity medicine physician with The Johns Hopkins Healthful Eating, Activity & Weight Program, tells SELF

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The placebo group differed from the reference population only in bodily pain and physical role functioning

doi: 10.1111/j.1447-0756.2012.01844.x

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