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Reduction in membrane surface by means of exocytosis during maturation of reticulocytes enables the cells to reduce or completely eliminate a number of receptors and ion transporters which play an active role in differentiation of erythroid precursor cells and are no longer required by mature RBC

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Since the 1950s, it has been shown to be safe and effective when used under medical supervision

doi: 10.1111/j.1651-2227.2010.02072.x 79 EisenachJHWittwerED

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