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The redox behavior of the NAD + /NADH system is therefore influenced by 1) the pH of the solution, since hydrogen ions participate in the redox half-reaction, 2) the 8 protonation states of NAD + , due to its three basic moieties, 3) the 16 protonation states of NADH, due to its four basic moieties (two pyrophosphate moieties, an adenine ring, and an added dihydropyridine ring)

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17 17141727 10.1089/ars.2012.4639 [DOI] [PMC free article] [PubMed] [Google Scholar] Youle R

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