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Harsh but true

"But, if they stop these medications, weight regain occurs in the vast majority of patients, and the metabolic benefits are lost," Dr Sullivan explained

doi: 10.1056/NEJMoa2206038 27 McInnesNHallSSultanFAronsonRHramiakIHarrisSet al

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In the obesity trials, participants on the 12 mg dose reached up to roughly 2829% mean body-weight reduction at 68 to 80 weeks, with a large share crossing the 25% and 30% thresholds, the strongest weight result reported for a GLP-1-class compound in a phase 3 trial [5]

These programs can also enroll eligible patients in clinical trials as they become available, which remains the safest path to accessing investigational pharmacotherapy for this age group