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Cocaine-induced headache: a review of pathogenesis, presentation, diagnosis, and management

G1, G2 and G3 showed onefold, 1.3 fold and 1.1 fold increase in activity of APX as compared to control

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Increase sales 20% Sales revenues: 30,000 1.20 $25.00 $900,000 Variable costs: 30,000 1.20 $15.00 540,000 Contribution margin 360,000 Fixed costs: ($174,000 + $30,000) 204,000 Operating income $ 156,000 3

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Protocol 1