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Therefore, clonidine therapy must always be tapered gradually over a minimum of 2 to 4 days (or weeks for higher doses), and any concurrent beta-blockers must be discontinued several days prior to beginning the taper (JAVADIN, 2025

The protection may be achieved because GLN restores the intestinal GSH content, normalizes the enzymatic activities of the antioxidant defense system and decreases the activation of the apoptotic pathway FASL/FAS/Caspase-3[88]

Therefore, inhibiting adrenergic receptors, especially 2-AR, may be an effective strategy to enhance chemotherapy efficacy 91

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