Following OPSW, cancer incidence rates per 1,000 person-years were reported, and Cox proportional hazards models were used to compare time-to-event outcomes during the follow-up period
Some cardiovascular outcome trials, such as the LEADER trial with liraglutide and the SUSTAIN-6 trial with semaglutide, included fracture events as safety endpoints
The pathway under study is melanogenesis, and the standard readouts are melanin content, the ratio of eumelanin to the lighter pigment, and tyrosinase activity as the rate-limiting enzyme step
Nevertheless, given the limitations of current evidence, robust randomized controlled trials with larger cohorts and longer follow-up are necessary to confirm these outcomes and further elucidate the therapeutic implications of GLP-1 RAs in hormonal regulation
Swallow the tablet whole with up to half a glass (approximately 120 mL) of plain water
Wegovy (injectable) Approved for weight loss in people with obesity or those overweight with at least one weight-related health condition (such as high blood pressure or type 2 diabetes)
