Given that obesity is a hallmark of BBS and a significant driver of its associated comorbidities, a deepening understanding of BBS5s role in metabolism could yield critical insights into disease pathogenesis
Conclusion Rethinking liver disease management through the lens of GLP1 therapy challenges traditional paradigms that have focused too narrowly on obesity or diabetes
In agreement, abundance of C56:1 TAG was inversely correlated with glucose levels at both 30 ( r = 0.67, P = 0.01) and 120 minutes ( r = 0.65, P = 0.02) in PBH, but not in the fasting state
Focus on incorporating: Protein-rich foods: Lean meats, fish, eggs, and legumes
These differences suggest involvement of the energy pathways in the development of PBH
This is particularly true for the retina, as it originates from neural ectoderm and connects to the brain by the optic nerve, which shares the meningeal layers of the brain