Patients in the clinical trials, who all have diabetes and/or obesity, also had fewer complaints about nausea and diarrhea
People with persistently dry mouth often develop gingivitis that can progress to more severe forms of gum disease if left untreated
In brown and beige adipose tissue, glucagon signaling increases uncoupling protein 1 (UCP1) expression and thermogenesis, directly raising resting energy expenditure
The generic version is manufactured by Hikma Pharmaceuticals and is expected to be available nationwide, offering a more affordable option for those relying on this medication for diabetes management
In public statements following the filing, Hims called the lawsuit "a blatant attack by a Danish company on millions of Americans who rely on compounded medications for access to personalized care." Novo challenged the efficacy of Hims's oral formulation and cited its own testing of compounded semaglutide products, reporting impurity levels of up to 86% in injectable formulations and up to 75% in oral formulations
The phase 2 trial published in the New England Journal of Medicine (Jastreboff et al., 2023) provides the most detailed data available on retatrutide fatigue