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Perturbed NAD + metabolism in response to infection Microbial infection, including viruses and bacteria, causes an imbalance in the cellular redox environment, thus inducing different responses, e.g., antioxidant defenses, cell signaling, immune response and other processes

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Taking metformin (Glucophage), which people with type 2 diabetes commonly use to control their blood sugar, may increase your risk of vitamin B12 deficiency, per the ODS