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In hyperuricemia management, synthetic gene networks integrating HucR-based biosensors and secreted Aspergillus flavus urate oxidase achieve self-regulated urate degradation, dynamically adjusting enzyme expression to maintain physiological UA levels while avoiding excessive urate depletion ( 2 O 2 neutralization, with enhanced renal targeting and catalytic durability (Tables 1 and 2

Given these roles, vitamin B6 deficiency can severely impact both the central and peripheral nervous systems (58)

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Ethics statement: Written informed consent was obtained from all subjects prior to participation, and the protocol was approved by the ethics committee in the Faculty of Pharmaceutical Sciences, Toho University (approval number 23-1, 24-6)

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