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Last reviewed: June 10, 2026 Last updated: June 10, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

I tracked my protein religiously

The dual mechanism explains why tirzepatide outperforms semaglutide, which activates only GLP-1

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in (INS-1)-cells

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By activating the glucagon receptor, it promotes the breakdown of fat for energy, potentially leading to even more significant weight loss