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Additionally, similar to docetaxel, the activation of pro-survival pathways such as the mitogen-activated protein kinase (MAPK) pathway can contribute to resistance by promoting cell survival and proliferation (66)

High intensity interval training combined with L-citrulline supplementation: effects on physical performance in healthy older adults

J Colloid Interface Sci 419:4651

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Treatment of the human skin model with alpha arbutin reduced melanin content to a 40% level of the control, without causing cell death [63]