For a 10 mg lyophilized vial: At 2.5 mg/week: 4 weeks of doses (perfectly matches the 28-day stability window) At 5 mg/week: 2 weeks of doses (well within stability limits) For a 30 mg lyophilized vial: At 2.5 mg/week: 12 weeks of doses (far exceeds 28-day window, significant waste) At 5 mg/week: 6 weeks (exceeds window by 2 weeks) At 7.5 mg/week: 4 weeks (perfect alignment) At 10 mg/week: 3 weeks (fully within stability limits) The reconstitution volume you choose affects how easy it is to measure each dose but does not change these timelines
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My bet is it was these people's immune system, which is unlike most of us as we get older, where we lose our fine tuning, the integrity [of our immune function], so its more vulnerable and it allows cancer cells to get going and spread, or it's untoward inflammation in our brain, in our body, in our arteries that sets up the other two diseases
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The pricing tells an interesting story, too