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Until properly designed, peer-reviewed human clinical trials are completedand an FDA-regulated production pathway existsclinicians should remain cautious and avoid its clinical use in patients

Seasonal considerations matter too

doi:10.1016/j.hermed.2020.100404 [16] Shahzad M, Yang X, Raza Asim MB, et al

For best penetration, apply to slightly damp skin or layer with a humectant like hyaluronic acid

Overall, these findings underscore the complexity of the molecular interactions with the neural circuitry underlying anxiety and highlight the necessity for a multifaceted approach in the design of anxiolytic treatments

Researchers must diligently assess new compounds before experimental use