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Interestingly, impaired vagal signaling may play a role in obesity, as decreased vagal activation to both mechanical stimuli and satiety-inducing signals is characteristic of a high-fat diet (HFD) 63,64,65,66
Short-term GLP-1 use can jumpstart that change by creating a window of reduced appetite and improved food awareness, but the weight stays off only if you maintain the behaviors learned during treatment
It should not be used as a drug, supplement, treatment, wellness product, or personal-use product
In addition, many studies suggest that -arrestins can also act as signaling molecules in their own right (3, 4)
J Neurochem 64:27732782 Ebert D, Haller RG, Walton ME (2003) Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy