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We then excluded compounds that are not yet approved for human use, have potential toxicity issues, were never marketed, or were not known to cross the bloodbrain barrier

This selectivity is important because it suggests the compound affects only its intended target rather than causing widespread metabolic disruption

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When treated with a vitamin B12-B6-folate combination, patients with mild cognitive impairment and hyperhomocysteinaemia appear to improve their blood-brain barrier function