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The same parameters were used in oral gavage experiments with danuglipron and orforglipron

In particular, the antidepressants fluoxetine (Prozac and Sarafem) and paroxetine have the ability to greatly reduce the effectiveness of tamoxifen as they are strong inhibitors of CYP2D6, therefore they should not be prescribed in conjunction with tamoxifen

If unmanaged, it can lead to severe complications

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