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It is designed around the pharmacokinetics of reaching steady state at each dose before adding more

Dehydration can slow digestion and increase feelings of discomfort

This delayed emptying augments both the volume and acidity of gastric contents at induction, increasing the odds of pulmonary aspiration during intubation

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Your individual response depends on multiple factors: your baseline weight, sleep quality, stress levels, other medications you're taking, and, most importantly, your diet and activity habits