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Dempsey discusses the use of GLP-1 medications for MCAS, including her most recent observations and recommendations
How many participants were studied
Psychiatry 13:821455
The most common side effects are acid reflux, constipation, fatigue, headaches, indigestion, mild nausea, and vomiting, which Saleh says are often eliminated or lessened as the medication stays in the body and you shift your lifestyle and eating habits. To minimize these side effects, avoid foods that are spicy or high in fat, and eat smaller, more frequent meals
(2021) trial tested cagrilintide at 0.3-4.5 mg weekly for 26 weeks in 706 adults: (Lau et al., 2021) Semaglutide Monotherapy (Phase 3) The STEP 1 trial tested semaglutide 2.4 mg weekly for 68 weeks in 1,961 adults: Mean weight loss: -14.9% =10% threshold: ~70% =15% threshold: ~54% =20% threshold: ~32% Important caveat: The semaglutide trial was 68 weeks versus only 26 weeks for cagrilintide
